Successful pilot analysis for Heart-Brain Connection project using XNAT and OpenClinica

Researchers from Erasmus MC, VUmc and LUMC have successfully performed a first analysis of multicenter data using XNAT and OpenClinica

Pilot analysis
This summer, a first subset of imaging and non-imaging data of the Heart-Brain Connection study were coupled and successfully used for statistical analyses. The analysis of the data of 40 participants was performed as a pilot to demonstrate that the researchers are able to bring together data from four sites. The pilot shows that the Heart-Brain consortium is in a good position to perform the main analyses of baseline study data in 2017.

Data for the Heart-Brain Connection study are centrally stored in platforms hosted by TraIT. XNAT is used for storing imaging data (heart and brain MRI scans) and OpenClinica for storing non-imaging data (clinical and cognitive parameters). Imaging data are processed by researchers at LUMC and Erasmus MC to extract parameters of heart and brain structure and function. Image processing results are centrally stored on XNAT next to the raw image data. The researchers implemented a quality assessment protocol to ensure consistency between the data stored in the two platforms.

Heart-Brain Connection
The Heart-Brain Connection,, is a multicenter study funded by Netherlands CardioVascular Research Initiative (CVON). The study aims to investigate the hypothesis that impaired hemodynamic status of both heart and brain is an important cause of vascular cognitive impairment offering promising opportunities for treatment. A wide range of imaging and non-imaging parameters of cardiovascular, hemodynamic, and cognitive functioning is assessed in patients with vascular cognitive impairment, heart failure, carotid occlusion disease, and healthy controls.